At the beginning of season 3, they mutually decided to get a divorce they remained friends. Hunter King as Clementine Hughes: (recurring season 1, main seasons 2–4) Daughter of Mary-Lynn niece of Spencer (her 'uncle-dad') dated Tyler Hughes from 'Babe Secret Phone Germs' until they married before 'Crytunes Divorce Tablet Ring'.She and John are still together but, in 'Crytunes Divorce Tablet Ring', they confessed to their kids that they got divorced in 1980 in protest when their best friends, a lesbian couple, couldn't get married.

Joan (Pirkle) Short: Partner of John Short therapist daughter of GiGi Pirkle mother of Heather (Short) Hughes, Matt Short, and Greg Short. In season one, he alludes to having served in the US Air Force and even makes reference to the US 101st Airborne Division. During season two when John was putting together his audition tap for 'Survivor', he introduces himself as 'John Bertram Short'. James Brolin as John Doe Short: Retired airline pilot partner of Joan (Pirkle) Short father of Heather (Short) Hughes, Matt Short, and Greg Short owns a female Yorkie named Tank since 'Sexting Mall Lemonade Heartbreak'.Giselle Eisenberg as Sophia Hughes: Youngest child and younger daughter of Tim and Heather Hughes sister of Tyler and Samantha Hughes.Barrett as Samantha 'Sam' Hughes: Middle child and older daughter of Tim and Heather Hughes sister of Tyler and Sophia Hughes. They got back together in the Season 3 episode 'Toilet Shaving Stuck Fertility'. It was mutual and decided to become friends. Beginning of season 3, they are getting divorced. Niall Cunningham as Tyler Hughes: Oldest child and only son of Tim and Heather Hughes brother of Samantha and Sophia Hughes dated Clementine from 'Babe Secret Phone Germs' until they married before 'Crytunes Divorce Tablet Ring'.They adopt Lucas, an orphan boy, before season 4 episode 6. They get married at the end of season 2, 'Poison Fire Teats Universe'. They get engaged in 'Crytunes Divorce Tablet Ring'. She and Matt get back together in 'Cinderella Fantasy Prom Dougie'. Angelique Cabral as Colleen Brandon Ortega Short: Granddaughter of Tonita owns a male puppy named 'Princess' dates Matt Short until the end of 'Hair Recital Rainbow Mom'.

Timothy 'Tim' Hughes, M.D.: An ENT doctor husband of Heather (Short) Hughes father of Tyler, Samantha, and Sophia Hughes. She gives birth to their second daughter in 'Lost Math Art Glam'. She told her husband that she is pregnant again in 'Video Piercing Model Hangover'. She announced that she is pregnant with their second child in season 1 finale, 'Crytunes Divorce Tablet Ring' however, it was later revealed that she had a miscarriage in the season 2 premiere, 'Annulled Roommate Pill Shower'.

Zoe Lister-Jones as Jennifer 'Jen' Collins Short: A lawyer mother of Lark and Talia Short wife of Greg Short.

They become engaged in the second half of the two-part season 1 finale, 'Crytunes Divorce Tablet Ring'. He and Colleen get back together in 'Cinderella Fantasy Prom Dougie'.

Thomas Sadoski as Matthew 'Matt' Short: Divorced shortly before season 1 began (wife was Bonnie) middle child and oldest son of John and Joan Short brother of Heather and Greg Short dates Colleen Brandon Ortega until the end of 'Hair Recital Rainbow Mom'.

Tim Hughes oldest child and only daughter of John and Joan Short older sister of Matt and Greg Short mother of Tyler, Samantha, and Sophia Hughes a stay at home mom.

Betsy Brandt as Heather (Short) Hughes: Wife of Dr.

He ends up running a small company by accident in 'Graffiti Cute Jewelry Shots'.

Colin Hanks as Gregory 'Greg' Short: Husband of Jen Short youngest child of John and Joan Short younger brother of Matt Short and Heather (Short) Hughes father of Lark and Talia Short worked for a crowd funding website until he quit his job in 'Crytunes Divorce Tablet Ring'.

Life in pieces cancelled